Acute phosphate nephropathy is a form of acute kidney injury associated with deposits of calcium-phosphate crystals in the renal tubules.  Acute phosphate nephropathy can result in permanent renal function impairment. This injury is a potential adverse reaction related to oral sodium phosphate (OSP) products.

OSPs are commonly used by patients preparing to undergo a colonoscopy (colon examination to detect precancerous growths) because OSP products cleanse the bowels.  Over-the-counter OSP products include the Fleet Phospho-soda products, manufactured by C.B. Fleet, which were voluntarily recalled by Fleet on December 11, 2008 and are no longer available in over-the-counter form.  Prescription OSP products include Visicol and OsmoPrep.

On December 11, 2008, the FDA required the manufacturer of Visicol and OsmoPrep to add a black box warning related to acute phosphate nephropathy caused by OSPs.

Published November 17, 2011 by