Amidst a growing number of Pradaxa lawsuits that claim life-threatening internal bleeding side effects, scientists at a San Francisco pharmaceutical company have successfully developed an antidote to two other anticoagulants used to prevent heart attacks and strokes in at-risk patients, according to Medicalxpress.com.

No Antidote Developed to Reverse Pradaxa Side Effects

Right now, there is no antidote to reverse Pradaxa side effects, which is why the excessive bleeding allegedly caused by the Boehringer-Ingelheim-manufactured blood thinner may be life-threatening and even fatal for many patients.

According to the Mar.5, 2013 article, scientists at Portola Therapeutics in San Francisco have created a recombinant protein that can reverse the effects of Eliquis (apixaban) and Xarelto (rivaroxaban), two anticoagulants that utilize factor Xa inhibitors to prevent blood clotting. These blood thinners were recently approved by the U.S. Food and Drug Administration (FDA).

The article states that Boehringer Ingelheim is in phase 1 testing of its own antidote to factor Ila inhibitor, Pradaxa. At the time it was approved by the FDA in 2010, this was the first anti-coagulant to be introduced in 50 years.

There is currently no readily available antidote to reverse the following Pradaxa side effects:

  • Cerebral hemorrhage – Pradaxa bleeding in the brain.
  • Severe Pradaxa internal bleeding following a minor trauma, such as a fall.
  • Gastrointestinal (stomach) bleeding.
  • Death from serious Pradaxa internal bleeding.

As of Dec. 31, 2011, approximately 500 deaths were connected to Pradaxa use, along with 3,781 adverse event reports of complication from patients who took the blood thinner.

Other pharmaceutical companies in the U.S. are also hard at work in developing antidotes to blood thinners. Perosphere, a startup pharmaceutical company based in Mount Kisco, N.Y. has created an antidote, PER977, which works to reverse the activity of the new factor Xa and factor IIa inhibitors as well.

Solomon Steiner, a chief executive of Perosphere, told Medicalxpress.com that creating an antidote for a wide range of anticoagulants is imperative for reaching the greatest number of patients, because many may not know the name of the blood thinner they are taking.

The side effects of warfarin, the most commonly-prescribed coagulant in the U.S., can be reversed with use of Vitamin K.

How to File a Lawsuit Claiming Pradaxa Side Effects

If you sustained excessive bleeding after taking Pradaxa, you may be eligible to file a Pradaxa lawsuit seeking compensation for medical expenses and lost wages, medical expenses, and other damages. Contact an attorney at Bernstein Liebhard LLP today at (877) 779-1414 to learn more about your legal rights.

Published March 21, 2013 by