May 6, 2010

Fosamax, a bisphosphonate drug, is used to treat osteoporosis as well as other bone diseases in men and women.  Over 40 million prescriptions have been written for this popular osteoporotic medication.  Fosamax was designed to inhibit osteoclasts to prevent bone resorption without any effect on mineralization. 

In December 18, 2010, the Clinical Orthopedic Related Research Journal reported 4 cases of women who experienced low-trauma Fosamax femur fractures while on Fosamax for more than 5 years.  Their X-rays showed the typical transverse fractures observed in some other Fosamax users.  One patient recovered by discontinuation of the therapy but the other 3 patients required surgical intervention and rehabilitation.  These unusual transverse fractures are not well understood at this time but there may be clinical relevance.  These authors state that, “although bisphosphonates play an important role in preventing pathological fractures in patients with cancer, these Fosamax femur fractures should not be ignored.

Fosamax Makes Television Debuts

On February 18, 2010 a television report from WCBD Charleston, S.C. presented an alert on Fosamax femur fractures entitled “Sudden Bone Breaks Reported in Patients Taking Fosamax.”  They reported observations made by Dr. Robert Bunning, a rheumatologist at the National Rehabilitation Hospital in Washington, D.C.  Bunning has remarked, “these drugs are supposed to work by shutting down the cells that re-absorb bone, the osteoclasts.  The ones that make bone, the osteoblasts, are supposed to keep working.  However, in biopsies of patients who have had this fracture, it shows that both are shut down.”   Bunning calls it “frozen bone” which is more brittle and more susceptible to these type of clean fractures.  There have been 50 to 60 reported cases of femur fractures that have occurred with no trauma with patients who have been on Fosamax for more than 5 years.  These patients report a vague thigh pain just before it happens. 

On March 8, 2010, ABC News also reported on Fosamax femur fractures allowing for greater public awareness.  There is mounting evidence now that women taking Fosamax for more than 5 years have the potential for generating spontaneous fractures.  The FDA states that they are aware of this problem and are actively investigating these types of fractures.

If you have experienced a Fosamax femur fracture or any other osteonecrotic disease while on Fosamax you may be entitled to financial compensation. Fosamax lawsuits are currently being filed across the country.


Susan Ardizzoni, Ph.D. holds a Doctorate in Biology with a major in Neuroscience (medical) and minors in Biochemistry, Physics, and Mathematics with experience in basic and clinical research.  Although the author is not an attorney, this article was sponsored by the law firm of Bernstein Liebhard LLP and constitutes Attorney Advertising.  To learn more about Fosamax femur fracture or Fosamax lawsuits please visit

Published November 17, 2011 by